In cultures with left-right-script, agentic behavior is mentally represented as following a left-to-right trajectory, an effect referred to as the Spatial Agency Bias. In this research, we investigated whether spatial representations of activities are universal across activities by analyzing the opposite concepts of “attack” and “defense”. Both behaviors involve similar actions but may differ in perceived agency. Moreover “defense” is necessarily always a response to an attack and may therefore be represented by a trajectory in the opposite direction. Two studies (...) found the classic SAB for activities representing attacking but a reduction and reversal for activities involving defense. Although the spatial representation of defense on the right was much weaker and less unequivocal than that of attack on the left, the results suggest that the spatial representations of defense and attack are located in different positions. Apparently not all actors and all activities are spatially represented on the left with a left-to-right trajectory but position and direction depend on the perceived agency. Directions for future research and applications of our findings are discussed. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

D. D. Raphael examines the moral philosophy of Adam Smith (1723-90), best known for his famous work on economics, The Wealth of Nations, and shows that his thought still has much to offer philosophers today. Raphael gives particular attention to Smith's original theory of conscience, with its emphasis on the role of 'sympathy' (shared feelings).

Research in the field of Empirical Ethics (EE) uses a broad variety of empirical methodologies, such as surveys, interviews and observation, developed in disciplines such as sociology, anthropology, and psychology. Whereas these empirical disciplines see themselves as purely descriptive, EE also aims at normative reflection. Currently there is literature about the quality of empirical research in ethics, but little or no reflection on specific methodological aspects that must be considered when conducting interdisciplinary empirical ethics. Furthermore, poor methodology in an EE (...) study results in misleading ethical analyses, evaluations or recommendations. This not only deprives the study of scientific and social value, but also risks ethical misjudgement. (shrink)

In this fascinating exploration of justice, eminent philosopher D. D. Raphael presents the culmination of a lifetime's study of its evolution, from ancient times to the late twentieth century. His aim is not just historical but philosophical: to illuminate our true understanding of justice. His unique approach examines not only classic texts by such philosophers as Plato, Aristotle, Hume, Mill, and Rawls but also the Bible and Greek tragedy, as well as some neglected but important thought from the modern (...) era. Lucid and stimulating, this work can be enjoyed by anyone interested in moral and political thought, even by those with little to no knowledge of political theory or philosophy. (shrink)

In this new and enlarged edition of a standard introduction to moral philosophy, Raphael shows in clear and simple language the connections between abstract ethics and practical problems in law, government, medicine, and the social sciences in general. Moral Philosophy deals with six main areas. First, it looks at the two opposed traditions of naturalism and rationalism, and considers more recent discussion in terms of logic and language. Next, it explores the attractions and defects of Utilitarianism, and then turns (...) to its main rival, Kantian ethics, which Raphael favors in a modified form. The third section shows how different moral views are related to different theories about justice and liberty. The fourth examines the problem of free will and determinism in the context of the presuppositions of science, especially in the social sciences. This second edition enlarges the relation of moral philosophy to other concerns, with two new chapters: one on ethics and evolution, the other on medical ethics. (shrink)

Kyle Stanford has recently given substance to the problem of unconceived alternatives, which challenges the reliability of inference to the best explanation (IBE) in remote domains of nature. Conjoined with the view that IBE is the central inferential tool at our disposal in investigating these domains, the problem of unconceived alternatives leads to scientific anti-realism. We argue that, at least within the biological community, scientists are now and have long been aware of the dangers of IBE. We re-analyse the nineteenth-century (...) study of inheritance and development (Stanford’s case study) and extend it into the twentieth century, focusing in particular on both classical Mendelian genetics and the studies by Avery et al. on the chemical nature of the hereditary substance. Our extended case studies show the preference of the biological community for a different methodological standard: the vera causa ideal, which requires that purported causes be shown on non-explanatory grounds to exist and be competent to produce their effects. On this basis, we defend a prospective realism about the biological sciences. 1 Introduction2 Stanford on Unconceived Alternatives3 Pangenesis: A Re-analysis4 The Vera Causa Ideal I: Negative Aspect5 Rendering Heredity Accessible6 The Vera Causa Ideal II: Positive Aspect7 Implications for Scientific Realism8 Conclusion. (shrink)

What responsibility do the Manhattan Project scientists have for the atomic devastation of Hiroshima? Krupps scientists for the crematoriums at Auschwitz? Is there no way to revisit the ideals of science once devoted to creating a more reasonable and open society free from prejudices? Disturbing questions like these are at the heart of this sobering exploration of scientific and intellectual responsibility.

The classical view of "rational man" as the unit of analysis for economic behavior and marketplace exchange has been changed by the late twentieth century with the help of behavioral economics that considers predictable irrationality as a normal mode of behavior. Instead of revising neoclassical economics to fit contemporary economic crises, it is recommended to follow Adam Smith's original concerns for the social setting of individual behavior and to treat economic crises with pragmatic flexibility rather than with dogmatic ideology.

1. Hobbes-Gay.--2. Hume-Bentham and Index.

1. The theory of classes presented in this paper is a simplification of that presented by J. von Neumann in his paper Die Axiomatisierung der Mengenlehre. However, this paper is written so that it can be read independently of von Neumann's. The principal modifications of his system are the following.(1) The idea of ordered pair is defined in terms of the other primitive concepts of the system. (See Axiom 4.3 below.)(2) A much simpler proof of the well-ordering theorem, based on (...) von Neumann's equivalence axiom (Axiom 2.2 below) is given. (More exactly, the theory of ordinal numbers, on which the proof of the well-ordering theorem is based, is simplified—see §8.)(3) Functions are not assumed to be defined for all arguments. In place of “ = A” we have “is undefined.” This makes possible a constructive interpretation of the system. (See §2.)2. We wish first to give a rough picture of the system which we are trying to construct. Suppose that we have the idea “class,” but no material from which to construct classes. Nevertheless, we can construct the class 0 having no elements. And then the class 1 having 0 as its only element. And then the classes {1}, and {0, 1}, etc., using always the previously constructed classes as elements. To extend this method to infinite classes, we must give rules telling what elements are to be included. Since the nature of the rules which we can use is not altogether clear, we try to formalize the whole system; that is, to set up a system of axioms which seems to characterize this system of classes. Now in this set of axioms we find it necessary to use the idea of function (in the “Axiom of Replacement”). (shrink)

This text was conceived as a synthetic introduction to the present-day situation of metaphysics and of ontology, to their stakes and their practices in the world and in France, by way of a preamble to the activities of the Atelier de métaphysique et d’ontologie contemporaines [Workshop on Contemporary Metaphysics and Ontology] at the École normale supérieure. It certainly does not claim to replace the more informed and complete works on which it rests, and which are indicated in the bibliography. Nor (...) was it written with the intention of being polemical against whatever conception of metaphysics, even if it goes without saying that the question is approached in a necssarily partisan, though resolutely conciliatory, manner. (shrink)

A biography of the black playwright who received great recognition for her work at an early age.

This article gives an overview of the mereological thought of the medieval philosopher and theologian Saint Thomas Aquinas. Until the 20th century mereology—the study of the relationship of whole and part—was not generally recognized as a distinct domain of philosophy and so Aquinas, like most of his contemporaries, has no single systematic treatment of it as a topic in its own right. However, a cohesive account of part‐whole relations can be pieced together from the various metaphysical, ethical and theological contexts (...) in which Aquinas deals with mereological issues. In this article, I give an account of both Aquinas's conceptual understanding of composition and his taxonomy of the different kinds of wholes and parts that there are. I end with comments on three marginal cases of mereological relationships in Aquinas's philosophy. (shrink)

I present an attempt at an explication of the ecological theory of interspecific competition, including its explanatory role in community ecology and evolutionary biology. The account given is based on the idea that law-like statements play an important role in scientific theories of this kind. I suggest that the principle of competitive exclusion is such a law, and that it is evolutionarily invariant. The principle's empirical status is defended and implications for the ongoing debates on the existence of biological laws (...) are discussed. (shrink)

The Controversy over the Existence of the World (henceforth Controversy) is the magnum opus of Polish philosopher Roman Ingarden. Despite the renewed interest for Ingarden’s pioneering ontological work whithin analytic philosophy, little attention has been dedicated to Controversy's main goal, clearly indicated by the very title of the book: finding a solution to the centuries-old philosophical controversy about the ontological status of the external world. -/- There are at least three reasons for this relative indifference. First, even at the time (...) when the book was published, the Controversy was no longer seen as a serious polemical topic, whether it was disqualified as an archaic metaphysical pseudo-problem, or taken to be the last remnant of an antiscientific approach to philosophy culminating in idealism and relativism. Second, Ingarden’s reasoning on the matter is highly complex, at times misleading, and even occasionally faulty. Finally, his analysis is not only incomplete – Controversy being unachieved – but also arguably aporetic. -/- One may wonder, then, why it is still worth excavating this mammoth treatise to study an issue apparently no longer relevant to contemporary philosophy. Aside from historical and exegetical purposes, which are of course very interesting in their own right, Ingarden’s treatment of the Controversy remains one of the most detailed and ambitious ontological undertakings of the twentieth century. Not only does it lay out an incredibly detailed map of possible solutions to the Controversy, but it also tries to show why the latter is a genuine and fundamental problem that owes its hasty disqualification to various oversimplifications over the course of the history of philosophy. -/- In this chapter, I first give an overview of Ingarden’s method, which relies mainly on a combinatorial analysis. Then, I summarize his examination of possible solutions to the Controversy, and determine which ones can be ruled out on ontological grounds. Finally, I explain why this ambitious project ultimately leads to a theoretical impasse, leaving Ingarden unable to come up with a definitive solution to the Controversy – regardless of the fact that the book is unachieved. I argue that his analysis of the problem yields a more modest but nonetheless valuable result. (shrink)

According to Spinoza, the categories of good and bad—in fact, all categories of value—are relative. The only valid category is that of substance; value as distinct from reality has no genuine meaning. Spinoza’s attack on valuation is based on two sets of arguments, one rationalistic and scientific, the other religious and theological. We will consider each in turn.

In The Methods of Ethics Sidgwick considers three ‘methods’, Egoistic Hedonism, Intuitionism, and Utilitarianism or Universalistic Hedonism. I propose to discuss his account of Intuitionism and its role in relation to the specific version of Utilitarianism that he himself adopts. To clear the decks I begin with some remarks on terminology.

Three-way baby making is not new: genetic surrogacy existed in Biblical times and donor insemination was recorded in Britain over 200 years ago. However, the gift of gametes between women breaks all social conventions. This paper examines the phenomenon of gamete-donation questioning whether a ‘gift’ of such magnitude can ever be ‘free’ (as the Human Fertilisation & Embryology Authority advocates), or a ‘true’ gift (in Derridian terms). Exploration of this unprecedented ‘gift’ from a psychoanalytic approach is supplemented by an interdisciplinary (...) one, drawing on the gift literature in philosophy, anthropology, ethnography and socioeconomics, as well as neonatal research and reproductive medicine. Critics note the dearth of analyses that take seriously the psychological ramifications of contemporary treatments, protocols and expectations in reproductive medicine. Based on psychoanalytic therapy within a clinical practice devoted to reproductive issues, the author argues that institutionalised asexual reproduction alters unconscious conceptualisations of the act of procreation – converting the passionate intimacy of primal scene into a clinical coupling of gametes in a mechanised arena. The author argues that, too charged to contemplate, the gamete's transcendent quality and blurring of elementary personae/res distinctions leads protagonists, including professionals, to defensive commodification. Multiple emotional meanings are ascribed to gifted gametes by each in the triangle of donor, recipient and offspring, illustrated here with verbatim material. This article addresses some of the far-reaching socio-political consequences for class, race, age, gender and sexuality of asexual reproduction, related to selection procedures and uneven global and local distribution of fertility treatment and its cost in financial, physical, practical and emotional terms. Similarly, feminist unease over (patriarchal) reproductive control and gatekeeping policies are considered, as well as ethical concerns over genetic manipulation, pre-implantation screening, sex selection, selective foetocide and potential exploitation of transnational donors and surrogates. (shrink)

This paper suggests that medical education be revised to assist in diffusing potential ethical dilemmas that arise during health care provision. A revised medical education would emphasize the role of the humanities in the training of physicians, especially in light of recent critiques of the canonical scientific model in general, and more specifically in the use of that model for medical training and practice.

The work of Karl Popper has had extraordinary influence across the fields of scientific and social thought. Widely regarded as one of the greatest philosophers of science of the twentieth century, he was also a highly influential social and political philosopher, a proponent and defender of the "open society". "Popper's Legacy" examines Popper in the round, analysing in particular his moral and psychological insights. Once Popper's scientific legacy is couched in political and moral terms, it becomes apparent that his concern (...) for individual autonomy does not come at the expense of institutional guidelines and social conventions. Instead, these guidelines turn out to be essential sanctions for individual freedom. Popper envisions the conduct of the scientific community as paralleling the conduct of any democratically established community. Critical rationality guides the words and actions of all participants and leadership can be replaced without violence. In presenting a critical overview, "Popper's Legacy" reveals the debt many intellectual movements - such as Marxism, feminism, and postmodernism - still owe to Popper. (shrink)

Introduction Moral concern for animals is commonly formulated in terms of concern for their welfare. Yet, besides the welfare issue, although highly ...

A scholarly edition of a work by Adam Smith. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

In our days, the creedal phrase 'I believe in God the Father almighty' is interpreted primarily along Trinitarian lines: It is applied to God as the Father of Jesus Christ. Here I argue that it has a dual background: in Jesus' prayer practice, in which He consistently addressed God as 'Father', and in the Hellenistic habit of referring to the Creator as 'Father'. I discuss Jesus' use of the term 'Father' against its Old Testament background, and argue that it primarily (...) points to the intimacy of Jesus' relationship with His father. Against the Hellenistic background, however, the metaphor 'Father' means 'he who brings forth effortlessly'. Finally, I discuss some gender issues connected with the use of the term 'Father' for God. (shrink)

Developments in the sequencing of whole genomes and in simultaneously surveying many thousands of transcription and translation products of specific cells have ushered in a conceptual revolution in genetics that rationally introduces top-down, holistic analyses. This emphasized the futility of attempts to reduce genes to structurally discrete entities along the genome, and the need to return to Johannsen's definition of a gene as 'something' that refers to an invariant entity of inheritance and development. We may view genes either as generic (...) terms for units of inheritance whose referents are pragmatic ad hoc and context-dependent, or as (epistemologically) representing entities of cell functions. It is cellular functions that determine the structural referents along the DNA. Structures that happened to secure specific functions that were essential for or conducive to the survival of cells were selected for. With natural selection being the etiological background of genes as functions, genes obtain again their theoretical role as intervening variables, abstractive variables that purely 'summarize' characters. The importance of DNA sequences is that of all possible phenotypes these are the most basic ones from which we can read off the genotype directly. (shrink)

According to Aristotle, phainomena or “appearances” provide the basis from which researches proceed. This shows that in spite of phainomena often corresponding to what falsely appears to be the case, there is genuine cognition through them. In this paper, I focus on two features of phainomenal cognition: accessibility and epistemological limitation. A phainomenal cognition of x is limited in the sense that there is always a stronger cognition of x to be attained. In this way, a research always aims at (...) surpassing the phainomenal cognition of its subject matter. On the other hand, phainomenal cognition is always somehow accessible. Resorting to the relation between phainomena and the distinction between the more intelligible to us and the more intelligible by nature, I intend to put forward a relative (as opposed to an absolute) understanding of both accessibility and epistemological limitation of phainomena. (shrink)

What darkness was the ‘Enlightenment’ supposed to have removed? The answer is irrational forms of religion. Most of the ‘enlightened’ took the view that revealed religion was irrational and that natural religion could be rational; but some were sceptical about natural religion too. Hume was the most honest and the most penetrating thinker of the latter group. His biographer, Professor E. C. Mossner, is not alone in believing that the Dialogues concerning Natural Religion is ‘his philosophical testament’.

My conclusions are the following:We can distinguish between two sorts of kowledge: intellectual knowledge (knowledge of true propositions) and experiential knowledge (knowledge of how certain experiences feel).If we want the doctrine of divine omniscience to be theologically relevant, we will have to assert that divine omniscience involves experiential as well as intellectual omniscience.In order to be omniscient, God does not need to share all the feelings of His creatures with them. However, in order to be experientially omniscient, God must have (...) undergone at least some experiences Himself.If God would be able to have these experiences only by becoming incarnate, God would need the incarnation in order to become omniscient. In this respect human nature would then be more perfect than the divine nature: it would be capable of knowing things which God could only come to know by becoming human. It is therefore preferable to maintain that the divine nature itself is capable of undergoing certain experiences.If the divine nature were incapable of undergoing any experience, God would nevertheless be able to have a vast knowledge of true propositions concerning experiences. For descriptions of experiences and for the evaluation of these descriptions, however, He would be dependent in principle upon His creatures. (shrink)